CD138/syndecan-1 (B-A38) Mouse Monoclonal Antibody
Specialties: Hematopathology
Detection of CD138 in neoplastic plasma cells by immunohistochemistry (IHC) with CD138/Syndecan-1 (B-A38) Mouse Monoclonal Antibody may be used to aid in the diagnosis of plasma cell myelomas (multiple myelomas).
CD138, also known as syndecan-1, is a cell surface heparan sulfate proteoglycan that plays a role in the inflammatory response, including leukocyte recruitment and adhesion.1 CD138 is normally highly expressed in plasma cells as well as both simple and stratified epithelia.1 CD138 is also expressed in the neoplastic plasma cells of multiple myeloma.1-4 Immunohistochemistry for CD138 shows a membranous pattern of staining.
- Chilosi, M et al. "CD138/syndecan-1: a useful immunohistochemical marker of normal and neoplastic plasma cells on routine trephine bone marrow biopsies." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 12,12 (1999): 1101-6.
- Sebestyén, A et al. "Syndecan-1 (CD138) expression in human non-Hodgkin lymphomas." British journal of haematology vol. 104,2 (1999): 412-9.
- Bayer-Garner, I B et al. "Syndecan-1 (CD138) immunoreactivity in bone marrow biopsies of multiple myeloma: shed syndecan-1 accumulates in fibrotic regions." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 14,10 (2001): 1052-8.
- O'Connell, Fionnuala P et al. "CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms." American journal of clinical pathology vol. 121,2 (2004): 254-63.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Membranous)
- Dilution Range: 1:25-1:200 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC13821070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 138M-10 |
| 0.1 mL concentrate | 138M-14 |
| 0.5 mL concentrate | 138M-15 |
| 1.0 mL concentrate | 138M-16 |
| 1.0 mL predilute ready-to-use | 138M-17 |
| 7.0 mL predilute ready-to-use | 138M-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 138M-10 |
| 0.1 mL concentrate | 138M-14 |
| 0.5 mL concentrate | 138M-15 |
| 1.0 mL concentrate | 138M-16 |
| 1.0 mL predilute ready-to-use | 138M-17 |
| 7.0 mL predilute ready-to-use | 138M-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 138M-10 |
| 0.1 mL concentrate | 138M-14 |
| 0.5 mL concentrate | 138M-15 |
| 1.0 mL concentrate | 138M-16 |
| 1.0 mL predilute ready-to-use | 138M-17 |
| 7.0 mL predilute ready-to-use | 138M-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 138M-10-RUO |
| 0.1 mL concentrate (RUO) | 138M-14-RUO |
| 0.5 mL concentrate (RUO) | 138M-15-RUO |
| 1.0 mL concentrate (RUO) | 138M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 138M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 138M-18-RUO |
| 15.0 mL predilute ready-to-use (RUO) | 138M-19-RUO |
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