CD61 (2f2) Mouse Monoclonal Antibody
Specialties: Hematopathology
Detection of CD61 expression in megakaryocytes by immunohistochemistry (IHC) with CD61 (2F2) Mouse Monoclonal Antibody may be used to aid in the diagnosis of chronic myeloid leukemia.
CD61 is an integrin cell-surface protein that functions in thrombus formation by acting as a binding receptor for fibrinogen, fibronectin, plasminogen, prothrombin, von Willebrand factor, and other prothrombotic molecules. CD61 is normally expressed on platelets, megakaryocytes, myeloid progenitor cells and endothelial cells.1-4 CD61 expression is also seen in acute megakaryoblastic leukemias.5 Immunohistochemistry for CD61 shows a cytoplasmic and membranous pattern of staining.
- Thiele, J et al. "An immunomorphometric study on megakaryocyte precursor cells in bone marrow tissue from patients with chronic myeloid leukemia (CML)." European journal of haematology vol. 44,1 (1990): 63-70.
- Thiele, J et al. "Megakaryocyte precursors (pro- and megakaryoblasts) in bone marrow tissue from patients with reactive thrombocytosis, polycythemia vera and primary (essential) thrombocythemia. An immunomorphometric study." Virchows Archiv. B, Cell pathology including molecular pathology vol. 58,4 (1990): 295-302.
- Fox, S B et al. "Megakaryocytes in myelodysplasia: an immunohistochemical study on bone marrow trephines." Histopathology vol. 17,1 (1990): 69-74.
- Thiele, J et al. "Megakaryocyte precursors (promegakaryoblasts and megakaryoblasts) in the normal human bone marrow. An immunohistochemical and morphometric study on routinely processed trephine biopsies." Analytical and quantitative cytology and histology vol. 12,4 (1990): 285-9.
- Gassmann, W, and H Löffler. "Acute megakaryoblastic leukemia." Leukemia & lymphoma vol. 18 Suppl 1 (1995): 69-73.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Non immunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Bone Marrow (Cytoplasmic)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC16121060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 161M-14 |
| 0.5 mL concentrate | 161M-15 |
| 1.0 mL concentrate | 161M-16 |
| 1.0 mL predilute ready-to-use | 161M-17 |
| 7.0 mL predilute ready-to-use | 161M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 161M-14 |
| 0.5 mL concentrate | 161M-15 |
| 1.0 mL concentrate | 161M-16 |
| 1.0 mL predilute ready-to-use | 161M-17 |
| 7.0 mL predilute ready-to-use | 161M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 161M-14 |
| 0.5 mL concentrate | 161M-15 |
| 1.0 mL concentrate | 161M-16 |
| 1.0 mL predilute ready-to-use | 161M-17 |
| 7.0 mL predilute ready-to-use | 161M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 161M-14-RUO |
| 0.5 mL concentrate (RUO) | 161M-15-RUO |
| 1.0 mL concentrate (RUO) | 161M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 161M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 161M-18-RUO |
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