CA-125 (OC125) on lung.
CA-125 (OC125) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Breast/Gynecological Pathology
Updated: 2023-05-01 08:50:39
CA-125 (cancer antigen 125) is a large transmembrane glycoprotein belonging to the mucin family, encoded by the gene MUC16. By immunohistochemistry, CA-125 expression is not identified in normal ovarian tissue, but it is found in normal cervix, fallopian tube, and endometrium.1-2 Positive immunostaining for CA-125 is seen in most ovarian carcinomas and epithelioid mesotheliomas.3-6
- Capobianco, G et al. "Immunohistochemical evaluation of a new epithelial antigen, BER-EP4 in ovarian cancer: a propos of 62 cases." European journal of gynaecological oncology vol. 33,1 (2012): 90-2.
- Eguchi, Takashi et al. "Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1." Oncotarget vol. 8,44 77872-77882. 12 Sep. 2017
- Kabawat, S E et al. "Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125." International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists vol. 2,3 (1983): 275-85.
- Davis, H M et al. "Characterization of the CA 125 antigen associated with human epithelial ovarian carcinomas." Cancer research vol. 46,12 Pt 1 (1986): 6143-8.
- Zhou, C et al. "Papillary serous carcinoma of the uterine cervix: a clinicopathologic study of 17 cases." The American journal of surgical pathology vol. 22,1 (1998): 113-20.
- Mylonas, I et al. "Immunohistochemical expression of the tumour marker CA-125 in normal, hyperplastic and malignant endometrial tissue." Anticancer research vol. 23,2A (2003): 1075-80.
Specifications
- Reactivity: paraffin
- Control: Ovarian Serous Carcinoma (Cytoplasmic, Membranous)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC32521050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 325M-14 |
| 0.5 mL concentrate | 325M-15 |
| 1.0 mL concentrate | 325M-16 |
| 1.0 mL predilute ready-to-use | 325M-17 |
| 7.0 mL predilute ready-to-use | 325M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 325M-14 |
| 0.5 mL concentrate | 325M-15 |
| 1.0 mL concentrate | 325M-16 |
| 1.0 mL predilute ready-to-use | 325M-17 |
| 7.0 mL predilute ready-to-use | 325M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 325M-14 |
| 0.5 mL concentrate | 325M-15 |
| 1.0 mL concentrate | 325M-16 |
| 1.0 mL predilute ready-to-use | 325M-17 |
| 7.0 mL predilute ready-to-use | 325M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 325M-14-RUO |
| 0.5 mL concentrate (RUO) | 325M-15-RUO |
| 1.0 mL concentrate (RUO) | 325M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 325M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 325M-18-RUO |
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