Synaptophysin (MRQ-40) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology
Detection of synaptophysin by immunohistochemistry (IHC) with Synaptophysin (MRQ-40) Rabbit Monoclonal Antibody may be used to aid in the diagnosis of neuroendocrine neoplasms.
Synaptophysin is an integral membrane protein of the presynaptic vesicles of neurons. Synaptophysin expression is seen normally in neurons, the adrenal medulla, and neuroendocrine cells which are found in the pancreas (islet cells), gastrointestinal tract, pituitary gland, and other sites.1,2 Synaptophysin expression is also found in neuroendocrine neoplasms including small cell carcinomas, large cell neuroendocrine carcinomas, and neuroendocrine tumors such as pancreatic neuroendocrine tumors and carcinoid tumors.2-6 Synaptophysin shows a cytoplasmic pattern of staining.
- Navone, F et al. "Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells."The Journal of cell biology vol. 103,6 Pt 1 (1986): 2511-27.
- Wiedenmann, B, and W W Franke. "Identifi cation and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles."Cell vol. 41,3 (1985): 1017-28.
- Wiedenmann, B et al. "Synaptophysin: a marker protein for neuroendocrine cells and neoplasms."  Proceedings of the National Academy of Sciences of the United States of America vol. 83,10 (1986): 3500-4.
- Kayser, K et al. "Expression of neuroendocrine markers (neuronspecific enolase, synaptophysin and bombesin) in carcinoma of the lung." Pathology, research and practice vol. 183,4 (1988): 412-7.
- Lyda, M H, and L M Weiss. "Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas.""Human pathology vol. 31,8 (2000): 980-7.
- Skacel, M et al. "Immunohistochemistry in the differential diagnosis of acinar and endocrine pancreatic neoplasms. " Applied immunohistochemistry & molecular morphology : AIMM  vol. 8,3 (2000): 203-9.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Non immunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Pancreatic islet cells (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC33639040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 336R-94 |
| 0.5 mL concentrate | 336R-95 |
| 1.0 mL concentrate | 336R-96 |
| 1.0 mL predilute ready-to-use | 336R-97 |
| 7.0 mL predilute ready-to-use | 336R-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 336R-94 |
| 0.5 mL concentrate | 336R-95 |
| 1.0 mL concentrate | 336R-96 |
| 1.0 mL predilute ready-to-use | 336R-97 |
| 7.0 mL predilute ready-to-use | 336R-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 336R-94 |
| 0.5 mL concentrate | 336R-95 |
| 1.0 mL concentrate | 336R-96 |
| 1.0 mL predilute ready-to-use | 336R-97 |
| 7.0 mL predilute ready-to-use | 336R-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 336R-94-RUO |
| 0.5 mL concentrate (RUO) | 336R-95-RUO |
| 1.0 mL concentrate (RUO) | 336R-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 336R-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 336R-98-RUO |
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