CD31 (JC70) Mouse Monoclonal Antibody
Specialties: Hematopathology Soft Tissue Pathology
Detection of CD31 by immunohistochemistry (IHC) with CD31 (JC70) Mouse Monoclonal Antibody may be used to identify normal blood vessels and to aid in the diagnosis of hemangiomas, Kaposi sarcomas and angiosarcomas.
CD31, or platelet/endothelial cell adhesion molecule-1 (PECAM-1), is a vascular cell adhesion and signaling molecule that plays a role in maintaining the vascular permeability barrier at endothelial cell junctions. CD31 expression is seen normally in vascular and lymphatic endothelial cells as well as in hematolymphoid cells, including megakaryocytes, macrophages, monocytes, and plasma cells. CD31 expression is seen in tumors of vascular origin including hemangiomas, Kaposi sarcomas and angiosarcomas.1-4 Immunohistochemistry for CD31 shows a cytoplasmic and membranous pattern of staining.
- Parums, D V et al. "JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections." Journal of clinical pathology vol. 43,9 (1990): 752-7.
- Attanoos, R L et al. "Malignant vascular tumours of the pleura in "asbestos" workers and endothelial differentiation in malignant mesothelioma." Thorax vol. 55,10 (2000): 860- 3.
- Abedalthagafi, Malak et al. "Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases." Annals of diagnostic pathology vol. 14,1 (2010): 15-22.
- Xu, Xiu-Lian et al. "Eruptive microvenular hemangiomas in 4 Chinese patients: clinicopathologic correlation and review of the literature." The American Journal of dermatopathology vol. 32,8 (2010): 837-40.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767.
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Cytoplasmic, Membranous)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC13129060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 131M-94 |
| 0.5 mL concentrate | 131M-95 |
| 1.0 mL concentrate | 131M-96 |
| 1.0 mL predilute ready-to-use | 131M-97 |
| 7.0 mL predilute ready-to-use | 131M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 131M-94 |
| 0.5 mL concentrate | 131M-95 |
| 1.0 mL concentrate | 131M-96 |
| 1.0 mL predilute ready-to-use | 131M-97 |
| 7.0 mL predilute ready-to-use | 131M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 131M-94 |
| 0.5 mL concentrate | 131M-95 |
| 1.0 mL concentrate | 131M-96 |
| 1.0 mL predilute ready-to-use | 131M-97 |
| 7.0 mL predilute ready-to-use | 131M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 131M-94-RUO |
| 0.5 mL concentrate (RUO) | 131M-95-RUO |
| 1.0 mL concentrate (RUO) | 131M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 131M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 131M-98-RUO |
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