Ep-CAM/Epithelial Specific Antigen (Ber-EP4) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Cytopathology
Detection of Ep-CAM with Ep-CAM/Epithelial Specific Antigen (Ber-EP4) Mouse Monoclonal Antibody may be used to aid in the diagnosis of lung adenocarcinomas.
Ep-CAM (epithelial cell adhesion molecule), which is recognized by the monoclonal antibody Ber-EP4, is a transmembrane glycoprotein localized on the membrane of epithelial cells that plays a role in epithelial cell adhesion and migration. Ep-CAM is normally expressed in epithelial cells including glandular, pseudo-stratified, and transitional epithelia but not in squamous epithelium, mesothelial cells, or hepatocytes.1,2 Ep-CAM expression has also been found in most lung adenocarcinomas, while it is usually not expressed in mesotheliomas.2-4 Immunohistochemistry for Ep-CAM (Ber-EP4) shows a cytoplasmic and membranous pattern of expression.
- Schnell, Ulrike et al. "EpCAM: structure and function in health and disease." Biochimica et biophysica acta vol. 1828,8 (2013): 1989-2001.
- Latza, U et al. "Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial." Journal of clinical pathology vol. 43,3 (1990): 213-9.
- Ordóñez, N G. "Value of the Ber-EP4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma. The M.D. Anderson experience and a critical review of the literature." American journal of clinical pathology vol. 109,1 (1998): 85-9.
- Ordóñez, Nelson G. "The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma." The American journal of surgical pathology vol. 27,8 (2003): 1031-51.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Adenocarcinoma (Cytoplasmic, Membranous)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC24829070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 248M-94 |
| 0.5 mL concentrate | 248M-95 |
| 1.0 mL concentrate | 248M-96 |
| 1.0 mL predilute ready-to-use | 248M-97 |
| 7.0 mL predilute ready-to-use | 248M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 248M-94 |
| 0.5 mL concentrate | 248M-95 |
| 1.0 mL concentrate | 248M-96 |
| 1.0 mL predilute ready-to-use | 248M-97 |
| 7.0 mL predilute ready-to-use | 248M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 248M-94 |
| 0.5 mL concentrate | 248M-95 |
| 1.0 mL concentrate | 248M-96 |
| 1.0 mL predilute ready-to-use | 248M-97 |
| 7.0 mL predilute ready-to-use | 248M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 248M-94-RUO |
| 0.5 mL concentrate (RUO) | 248M-95-RUO |
| 1.0 mL concentrate (RUO) | 248M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 248M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 248M-98-RUO |
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